While there’s much focus in the field of neuroscience regarding cerebral blood flow (CBF) and it’s correlation with brain activity, CSF has also been found to be a distribution medium of neuroactive substances influencing brain states.įrom the many discussions regarding DMT and WHM throughout the internet, its seems as though it is a very polarizing topic. A 2017 study in The Journal of Neuroscience observed that breathing controls the circulation of CSF throughout the brain. This fluid is found throughout the brain and spinal cord. The particular finding of the choroid plexus involvement is especially intriguing being that this part of the brain is primarily responsible for producing cerebrospinal fluid (CSF). Nevertheless, based on the recent finding that the enzymes needed to produce DMT are found throughout the pineal gland, choroid plexus, and cerebral cortex, it seems realistic that DMT plays a key role in modulating everyday perception. This makes it fairly difficult to extrapolate in-depth meaning from blood samples when attempting to understand what is taking place in the brain. For example, the chemical oxytocin, known as the 'love hormone' exudes levels in the brain that are 100,000 percent greater than the amount found circulating in the blood. Other methods of generating data such as taking blood samples are also challenging being that blood levels are not entirely indicative of levels found in the brain. While this can be undertaken in rats, unless humans develop a communication method to teach rats WHM, it would be difficult to extract comparable data to human subjects. You’re essentially sticking needles in the brain to take fluid samples. The difficulties in testing this scientifically are due to the invasive methods of extracting cerebral fluid via micro-dialysis. The real question is whether WHM increases the level of DMT in the brain correlating with the subsequent visionary effects. It seems clear based on the data that DMT is always produced throughout the brain. This is an important finding based on the question of whether physiological relevant levels of DMT can be produced in the brain.Īt this point, the question is not whether WHM produces DMT. In addition to the data indicating that DMT is produced throughout the brain, it was also found that extracellular levels of DMT in the brain were comparable to serotonin, dopamine, and norepinephrine in live rats. The study was titled, 'Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain'. However, a ground-breaking study out of the Borjigin Lab at the University of Michigan was published showcasing that INMT is found throughout the cerebral cortex, the choroid plexus, and the pineal gland of rats and humans. This enzyme (INMT) is also found throughout the lungs which provided the foundation for the hypothesis that the lungs were a major source of DMT. In addition to secreting DMT, the pineal gland was also found to contain the enzyme necessary (Indolethylamine N-Methyltransferase (INMT)) to convert tryptamine to DMT. Being that the internal physiology of rats, humans, and many mammalian counterparts are extremely similar, it is believed that the pineal gland of humans also secretes DMT. It was found to secrete DMT in a 2013 rat study published in the journal Biomedical Chromatography. This gland is a small endocrine organ located in the middle of the mammalian brain. In the past, much of the discussion surrounding endogenous DMT has been in regards to the pineal gland. It’s a reasonable hypothesis based on there being no other endogenous hallucinogens currently identified (other than DMT related compounds 5-MEO-DMT & Bufotenin). This is due to the fact that many practitioners of WHM report having hallucinatory/visionary experiences especially when partaking in the breathing exercises for extended periods of time (over 30 consecutive minutes). There’s been much speculation pertaining to the Wim Hof Method (WHM) and dimethyltryptamine (DMT), an endogenous hallucinogen produced by the human body.
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